Sequencing and analysis of the genome of mycobacterium tuberculosis complex from an isolate or nucleic acid extract: (a) to speciate the organism: (i) at the time of a patient’s initial diagnosis and commencement of initial empiric therapy; or (ii) following recurrence of a patient’s symptoms or a patient’s failure to respond to treatment within the expected timeframe; and (b) for the purpose of: (i) genome‑wide determination of the antimicrobial resistance markers (resistome) of the isolate; and (ii) individualising the patient’s treatment Applicable once at initial diagnosis and once per episode of disease recurrence